<?xml version="1.0" encoding="UTF-8"?>
<sbml xmlns="http://www.sbml.org/sbml/level2/version4" level="2" version="4">
  <model id="Ec_core">
    <listOfCompartments>
      <compartment id="default" size="1"/>
    </listOfCompartments>
    <listOfSpecies>
      <species id="M_akg_e" compartment="default"/>
      <species id="M_co2_e" compartment="default"/>
      <species id="M_pi_c" compartment="default"/>
      <species id="M_ru5p_D_c" compartment="default"/>
      <species id="M_akg_b" compartment="default"/>
      <species id="M_adp_c" compartment="default"/>
      <species id="M_etoh_c" compartment="default"/>
      <species id="M_r5p_c" compartment="default"/>
      <species id="M_co2_c" compartment="default"/>
      <species id="M_g6p_c" compartment="default"/>
      <species id="M_h_e" compartment="default"/>
      <species id="M_etoh_e" compartment="default"/>
      <species id="M_3pg_c" compartment="default"/>
      <species id="M_glc_D_b" compartment="default"/>
      <species id="M_h2o_e" compartment="default"/>
      <species id="M_co2_b" compartment="default"/>
      <species id="M_lac_D_b" compartment="default"/>
      <species id="M_oaa_c" compartment="default"/>
      <species id="M_o2_e" compartment="default"/>
      <species id="M_h_c" compartment="default"/>
      <species id="M_2pg_c" compartment="default"/>
      <species id="M_o2_c" compartment="default"/>
      <species id="M_o2_b" compartment="default"/>
      <species id="M_nadh_c" compartment="default"/>
      <species id="M_etoh_b" compartment="default"/>
      <species id="M_pyr_c" compartment="default"/>
      <species id="M_fum_b" compartment="default"/>
      <species id="M_accoa_c" compartment="default"/>
      <species id="M_nadp_c" compartment="default"/>
      <species id="M_nad_c" compartment="default"/>
      <species id="M_ac_b" compartment="default"/>
      <species id="M_nadph_c" compartment="default"/>
      <species id="M_h2o_b" compartment="default"/>
      <species id="M_lac_D_e" compartment="default"/>
      <species id="M_ac_e" compartment="default"/>
      <species id="M_q8_c" compartment="default"/>
      <species id="M_for_e" compartment="default"/>
      <species id="M_succ_e" compartment="default"/>
      <species id="M_6pgl_c" compartment="default"/>
      <species id="M_mal_L_c" compartment="default"/>
      <species id="M_for_b" compartment="default"/>
      <species id="M_ac_c" compartment="default"/>
      <species id="M_icit_c" compartment="default"/>
      <species id="M_pi_e" compartment="default"/>
      <species id="M_lac_D_c" compartment="default"/>
      <species id="M_atp_c" compartment="default"/>
      <species id="M_amp_c" compartment="default"/>
      <species id="M_pi_b" compartment="default"/>
      <species id="M_pyr_e" compartment="default"/>
      <species id="M_pyr_b" compartment="default"/>
      <species id="M_succ_b" compartment="default"/>
      <species id="M_6pgc_c" compartment="default"/>
      <species id="M_fum_e" compartment="default"/>
      <species id="M_h2o_c" compartment="default"/>
      <species id="M_f6p_c" compartment="default"/>
      <species id="M_xu5p_D_c" compartment="default"/>
      <species id="M_pep_c" compartment="default"/>
      <species id="M_glx_c" compartment="default"/>
      <species id="M_q8h2_c" compartment="default"/>
      <species id="M_fdp_c" compartment="default"/>
      <species id="M_actp_c" compartment="default"/>
      <species id="M_glc_D_e" compartment="default"/>
      <species id="M_fad_c" compartment="default"/>
      <species id="M_h_b" compartment="default"/>
      <species id="M_fadh2_c" compartment="default"/>
      <species id="M_coa_c" compartment="default"/>
      <species id="M_for_c" compartment="default"/>
    </listOfSpecies>
    <listOfReactions>
      <reaction id="R_O2t" reversible="false">
        <listOfReactants>
          <speciesReference species="M_o2_e"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_o2_c"/>
        </listOfProducts>
      </reaction>
      <reaction id="R_PTAr" reversible="false">
        <listOfReactants>
          <speciesReference species="M_pi_c"/>
          <speciesReference species="M_accoa_c"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_actp_c"/>
          <speciesReference species="M_coa_c"/>
        </listOfProducts>
      </reaction>
      <reaction id="rR_EX_lac_D_e_" reversible="false">
        <listOfReactants>
          <speciesReference species="M_lac_D_b"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_lac_D_e"/>
        </listOfProducts>
      </reaction>
      <reaction id="rR_EX_pyr_e_" reversible="false">
        <listOfReactants>
          <speciesReference species="M_pyr_b"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_pyr_e"/>
        </listOfProducts>
      </reaction>
      <reaction id="R_FORt" reversible="false">
        <listOfReactants>
          <speciesReference species="M_for_e"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_for_c"/>
        </listOfProducts>
      </reaction>
      <reaction id="rR_G6PDH2r" reversible="false">
        <listOfReactants>
          <speciesReference species="M_nadph_c"/>
          <speciesReference species="M_h_c"/>
          <speciesReference species="M_6pgl_c"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_nadp_c"/>
          <speciesReference species="M_g6p_c"/>
        </listOfProducts>
      </reaction>
      <reaction id="R_EX_h_e_" reversible="false">
        <listOfReactants>
          <speciesReference species="M_h_e"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_h_b"/>
        </listOfProducts>
      </reaction>
      <reaction id="rR_PTAr" reversible="false">
        <listOfReactants>
          <speciesReference species="M_actp_c"/>
          <speciesReference species="M_coa_c"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_pi_c"/>
          <speciesReference species="M_accoa_c"/>
        </listOfProducts>
      </reaction>
      <reaction id="R_PYRt2r" reversible="false">
        <listOfReactants>
          <speciesReference species="M_pyr_e"/>
          <speciesReference species="M_h_e"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_pyr_c"/>
          <speciesReference species="M_h_c"/>
        </listOfProducts>
      </reaction>
      <reaction id="M7" reversible="false">
        <listOfReactants>
          <speciesReference species="M_f6p_c" stoichiometry="0.0103304206067807"/>
          <speciesReference species="M_pyr_c" stoichiometry="0.0370571299162842"/>
          <speciesReference species="M_icit_c" stoichiometry="0.285437598750318"/>
          <speciesReference species="M_accoa_c" stoichiometry="0.0490266561353607"/>
          <speciesReference species="M_nadp_c" stoichiometry="0.0470281830752685"/>
          <speciesReference species="M_pep_c" stoichiometry="0.00679058039379522"/>
          <speciesReference species="M_r5p_c" stoichiometry="0.00940294584292063"/>
          <speciesReference species="M_atp_c" stoichiometry="0.0219839390723505"/>
          <speciesReference species="M_nad_c" stoichiometry="0.75309193904818"/>
          <speciesReference species="M_g6p_c" stoichiometry="0.00268169713104993"/>
          <speciesReference species="M_fdp_c" stoichiometry="0.222059098250918"/>
          <speciesReference species="M_fad_c" stoichiometry="0.271324022971344"/>
          <speciesReference species="M_oaa_c" stoichiometry="0.0233726256782776"/>
          <speciesReference species="M_h2o_c"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_3pg_c" stoichiometry="0.415798166653007"/>
          <speciesReference species="M_pi_c" stoichiometry="0.0219839390723505"/>
          <speciesReference species="M_mal_L_c" stoichiometry="0.271324022971344"/>
          <speciesReference species="M_nadh_c" stoichiometry="0.75309193904818"/>
          <speciesReference species="M_xu5p_D_c" stoichiometry="0.00940294584292004"/>
          <speciesReference species="M_adp_c" stoichiometry="0.0219839390723505"/>
          <speciesReference species="M_fadh2_c" stoichiometry="0.271324022971344"/>
          <speciesReference species="M_co2_c" stoichiometry="0.556761621721661"/>
          <speciesReference species="M_h_c" stoichiometry="0.972034477430443"/>
          <speciesReference species="M_nadph_c" stoichiometry="0.0470281830752685"/>
          <speciesReference species="M_coa_c" stoichiometry="0.0490266561353607"/>
        </listOfProducts>
      </reaction>
      <reaction id="rR_EX_pi_e_" reversible="false">
        <listOfReactants>
          <speciesReference species="M_pi_b"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_pi_e"/>
        </listOfProducts>
      </reaction>
      <reaction id="rR_ENO" reversible="false">
        <listOfReactants>
          <speciesReference species="M_pep_c"/>
          <speciesReference species="M_h2o_c"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_2pg_c"/>
        </listOfProducts>
      </reaction>
      <reaction id="R_PPS" reversible="false">
        <listOfReactants>
          <speciesReference species="M_pyr_c"/>
          <speciesReference species="M_atp_c"/>
          <speciesReference species="M_h2o_c"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_pi_c"/>
          <speciesReference species="M_pep_c"/>
          <speciesReference species="M_h_c" stoichiometry="2"/>
          <speciesReference species="M_amp_c"/>
        </listOfProducts>
      </reaction>
      <reaction id="rR_PGM" reversible="false">
        <listOfReactants>
          <speciesReference species="M_3pg_c"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_2pg_c"/>
        </listOfProducts>
      </reaction>
      <reaction id="R_EX_for_e_" reversible="false">
        <listOfReactants>
          <speciesReference species="M_for_e"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_for_b"/>
        </listOfProducts>
      </reaction>
      <reaction id="rR_EX_h_e_" reversible="false">
        <listOfReactants>
          <speciesReference species="M_h_b"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_h_e"/>
        </listOfProducts>
      </reaction>
      <reaction id="R_EX_h2o_e_" reversible="false">
        <listOfReactants>
          <speciesReference species="M_h2o_e"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_h2o_b"/>
        </listOfProducts>
      </reaction>
      <reaction id="rR_ADHEr" reversible="false">
        <listOfReactants>
          <speciesReference species="M_etoh_c"/>
          <speciesReference species="M_nad_c" stoichiometry="2"/>
          <speciesReference species="M_coa_c"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_nadh_c" stoichiometry="2"/>
          <speciesReference species="M_accoa_c"/>
          <speciesReference species="M_h_c" stoichiometry="2"/>
        </listOfProducts>
      </reaction>
      <reaction id="R_ATPM" reversible="false">
        <listOfReactants>
          <speciesReference species="M_atp_c"/>
          <speciesReference species="M_h2o_c"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_pi_c"/>
          <speciesReference species="M_adp_c"/>
          <speciesReference species="M_h_c"/>
        </listOfProducts>
      </reaction>
      <reaction id="R_SUCD4" reversible="false">
        <listOfReactants>
          <speciesReference species="M_q8_c"/>
          <speciesReference species="M_fadh2_c"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_q8h2_c"/>
          <speciesReference species="M_fad_c"/>
        </listOfProducts>
      </reaction>
      <reaction id="rR_PYRt2r" reversible="false">
        <listOfReactants>
          <speciesReference species="M_pyr_c"/>
          <speciesReference species="M_h_c"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_pyr_e"/>
          <speciesReference species="M_h_e"/>
        </listOfProducts>
      </reaction>
      <reaction id="M3" reversible="false">
        <listOfReactants>
          <speciesReference species="M_accoa_c"/>
          <speciesReference species="M_oaa_c"/>
          <speciesReference species="M_h2o_c"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_icit_c"/>
          <speciesReference species="M_h_c"/>
          <speciesReference species="M_coa_c"/>
        </listOfProducts>
      </reaction>
      <reaction id="R_PFK" reversible="false">
        <listOfReactants>
          <speciesReference species="M_f6p_c"/>
          <speciesReference species="M_atp_c"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_fdp_c"/>
          <speciesReference species="M_adp_c"/>
          <speciesReference species="M_h_c"/>
        </listOfProducts>
      </reaction>
      <reaction id="rR_RPE" reversible="false">
        <listOfReactants>
          <speciesReference species="M_xu5p_D_c"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_ru5p_D_c"/>
        </listOfProducts>
      </reaction>
      <reaction id="rR_O2t" reversible="false">
        <listOfReactants>
          <speciesReference species="M_o2_c"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_o2_e"/>
        </listOfProducts>
      </reaction>
      <reaction id="R_MALS" reversible="false">
        <listOfReactants>
          <speciesReference species="M_accoa_c"/>
          <speciesReference species="M_glx_c"/>
          <speciesReference species="M_h2o_c"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_mal_L_c"/>
          <speciesReference species="M_h_c"/>
          <speciesReference species="M_coa_c"/>
        </listOfProducts>
      </reaction>
      <reaction id="R_FBP" reversible="false">
        <listOfReactants>
          <speciesReference species="M_fdp_c"/>
          <speciesReference species="M_h2o_c"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_pi_c"/>
          <speciesReference species="M_f6p_c"/>
        </listOfProducts>
      </reaction>
      <reaction id="R_RPE" reversible="false">
        <listOfReactants>
          <speciesReference species="M_ru5p_D_c"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_xu5p_D_c"/>
        </listOfProducts>
      </reaction>
      <reaction id="rR_MDH" reversible="false">
        <listOfReactants>
          <speciesReference species="M_nadh_c"/>
          <speciesReference species="M_oaa_c"/>
          <speciesReference species="M_h_c"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_mal_L_c"/>
          <speciesReference species="M_nad_c"/>
        </listOfProducts>
      </reaction>
      <reaction id="R_PGM" reversible="false">
        <listOfReactants>
          <speciesReference species="M_2pg_c"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_3pg_c"/>
        </listOfProducts>
      </reaction>
      <reaction id="rR_PGI" reversible="false">
        <listOfReactants>
          <speciesReference species="M_f6p_c"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_g6p_c"/>
        </listOfProducts>
      </reaction>
      <reaction id="rR_ACt2r" reversible="false">
        <listOfReactants>
          <speciesReference species="M_ac_c"/>
          <speciesReference species="M_h_c"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_ac_e"/>
          <speciesReference species="M_h_e"/>
        </listOfProducts>
      </reaction>
      <reaction id="R_PPC" reversible="false">
        <listOfReactants>
          <speciesReference species="M_pep_c"/>
          <speciesReference species="M_co2_c"/>
          <speciesReference species="M_h2o_c"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_pi_c"/>
          <speciesReference species="M_oaa_c"/>
          <speciesReference species="M_h_c"/>
        </listOfProducts>
      </reaction>
      <reaction id="rR_H2Ot" reversible="false">
        <listOfReactants>
          <speciesReference species="M_h2o_c"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_h2o_e"/>
        </listOfProducts>
      </reaction>
      <reaction id="rR_ATPS4r" reversible="false">
        <listOfReactants>
          <speciesReference species="M_atp_c"/>
          <speciesReference species="M_h_c" stoichiometry="3"/>
          <speciesReference species="M_h2o_c"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_pi_c"/>
          <speciesReference species="M_adp_c"/>
          <speciesReference species="M_h_e" stoichiometry="4"/>
        </listOfProducts>
      </reaction>
      <reaction id="R_D_LACt2" reversible="false">
        <listOfReactants>
          <speciesReference species="M_lac_D_e"/>
          <speciesReference species="M_h_e"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_lac_D_c"/>
          <speciesReference species="M_h_c"/>
        </listOfProducts>
      </reaction>
      <reaction id="rR_RPI" reversible="false">
        <listOfReactants>
          <speciesReference species="M_ru5p_D_c"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_r5p_c"/>
        </listOfProducts>
      </reaction>
      <reaction id="R_LDH_D" reversible="false">
        <listOfReactants>
          <speciesReference species="M_lac_D_c"/>
          <speciesReference species="M_nad_c"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_nadh_c"/>
          <speciesReference species="M_pyr_c"/>
          <speciesReference species="M_h_c"/>
        </listOfProducts>
      </reaction>
      <reaction id="rR_EX_co2_e_" reversible="false">
        <listOfReactants>
          <speciesReference species="M_co2_b"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_co2_e"/>
        </listOfProducts>
      </reaction>
      <reaction id="rR_EX_glc_e_" reversible="false">
        <listOfReactants>
          <speciesReference species="M_glc_D_b"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_glc_D_e"/>
        </listOfProducts>
      </reaction>
      <reaction id="R_EX_pyr_e_" reversible="false">
        <listOfReactants>
          <speciesReference species="M_pyr_e"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_pyr_b"/>
        </listOfProducts>
      </reaction>
      <reaction id="rR_PIt" reversible="false">
        <listOfReactants>
          <speciesReference species="M_pi_e"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_pi_c"/>
        </listOfProducts>
      </reaction>
      <reaction id="rR_LDH_D" reversible="false">
        <listOfReactants>
          <speciesReference species="M_nadh_c"/>
          <speciesReference species="M_pyr_c"/>
          <speciesReference species="M_h_c"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_lac_D_c"/>
          <speciesReference species="M_nad_c"/>
        </listOfProducts>
      </reaction>
      <reaction id="R_PDH" reversible="false">
        <listOfReactants>
          <speciesReference species="M_pyr_c"/>
          <speciesReference species="M_nad_c"/>
          <speciesReference species="M_coa_c"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_nadh_c"/>
          <speciesReference species="M_accoa_c"/>
          <speciesReference species="M_co2_c"/>
        </listOfProducts>
      </reaction>
      <reaction id="R_EX_succ_e_" reversible="false">
        <listOfReactants>
          <speciesReference species="M_succ_e"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_succ_b"/>
        </listOfProducts>
      </reaction>
      <reaction id="rR_CO2t" reversible="false">
        <listOfReactants>
          <speciesReference species="M_co2_c"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_co2_e"/>
        </listOfProducts>
      </reaction>
      <reaction id="R_EX_etoh_e_" reversible="false">
        <listOfReactants>
          <speciesReference species="M_etoh_e"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_etoh_b"/>
        </listOfProducts>
      </reaction>
      <reaction id="rR_EX_fum_e_" reversible="false">
        <listOfReactants>
          <speciesReference species="M_fum_b"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_fum_e"/>
        </listOfProducts>
      </reaction>
      <reaction id="R_PYK" reversible="false">
        <listOfReactants>
          <speciesReference species="M_adp_c"/>
          <speciesReference species="M_pep_c"/>
          <speciesReference species="M_h_c"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_pyr_c"/>
          <speciesReference species="M_atp_c"/>
        </listOfProducts>
      </reaction>
      <reaction id="R_EX_pi_e_" reversible="false">
        <listOfReactants>
          <speciesReference species="M_pi_e"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_pi_b"/>
        </listOfProducts>
      </reaction>
      <reaction id="R_ACKr" reversible="false">
        <listOfReactants>
          <speciesReference species="M_ac_c"/>
          <speciesReference species="M_atp_c"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_actp_c"/>
          <speciesReference species="M_adp_c"/>
        </listOfProducts>
      </reaction>
      <reaction id="R_PGI" reversible="false">
        <listOfReactants>
          <speciesReference species="M_g6p_c"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_f6p_c"/>
        </listOfProducts>
      </reaction>
      <reaction id="R_ME1" reversible="false">
        <listOfReactants>
          <speciesReference species="M_mal_L_c"/>
          <speciesReference species="M_nad_c"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_nadh_c"/>
          <speciesReference species="M_pyr_c"/>
          <speciesReference species="M_co2_c"/>
        </listOfProducts>
      </reaction>
      <reaction id="R_CO2t" reversible="false">
        <listOfReactants>
          <speciesReference species="M_co2_e"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_co2_c"/>
        </listOfProducts>
      </reaction>
      <reaction id="rR_EX_akg_e_" reversible="false">
        <listOfReactants>
          <speciesReference species="M_akg_b"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_akg_e"/>
        </listOfProducts>
      </reaction>
      <reaction id="R_EX_o2_e_" reversible="false">
        <listOfReactants>
          <speciesReference species="M_o2_e"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_o2_b"/>
        </listOfProducts>
      </reaction>
      <reaction id="R_EX_lac_D_e_" reversible="false">
        <listOfReactants>
          <speciesReference species="M_lac_D_e"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_lac_D_b"/>
        </listOfProducts>
      </reaction>
      <reaction id="rR_EX_o2_e_" reversible="false">
        <listOfReactants>
          <speciesReference species="M_o2_b"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_o2_e"/>
        </listOfProducts>
      </reaction>
      <reaction id="R_GLCpts" reversible="false">
        <listOfReactants>
          <speciesReference species="M_glc_D_e"/>
          <speciesReference species="M_pep_c"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_pyr_c"/>
          <speciesReference species="M_g6p_c"/>
        </listOfProducts>
      </reaction>
      <reaction id="R_GND" reversible="false">
        <listOfReactants>
          <speciesReference species="M_6pgc_c"/>
          <speciesReference species="M_nadp_c"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_ru5p_D_c"/>
          <speciesReference species="M_co2_c"/>
          <speciesReference species="M_nadph_c"/>
        </listOfProducts>
      </reaction>
      <reaction id="rR_ETOHt2r" reversible="false">
        <listOfReactants>
          <speciesReference species="M_etoh_c"/>
          <speciesReference species="M_h_c"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_h_e"/>
          <speciesReference species="M_etoh_e"/>
        </listOfProducts>
      </reaction>
      <reaction id="R_G6PDH2r" reversible="false">
        <listOfReactants>
          <speciesReference species="M_nadp_c"/>
          <speciesReference species="M_g6p_c"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_nadph_c"/>
          <speciesReference species="M_h_c"/>
          <speciesReference species="M_6pgl_c"/>
        </listOfProducts>
      </reaction>
      <reaction id="R_ETOHt2r" reversible="false">
        <listOfReactants>
          <speciesReference species="M_h_e"/>
          <speciesReference species="M_etoh_e"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_etoh_c"/>
          <speciesReference species="M_h_c"/>
        </listOfProducts>
      </reaction>
      <reaction id="R_EX_fum_e_" reversible="false">
        <listOfReactants>
          <speciesReference species="M_fum_e"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_fum_b"/>
        </listOfProducts>
      </reaction>
      <reaction id="rR_FORt" reversible="false">
        <listOfReactants>
          <speciesReference species="M_for_c"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_for_e"/>
        </listOfProducts>
      </reaction>
      <reaction id="R_NADTRHD" reversible="false">
        <listOfReactants>
          <speciesReference species="M_nadph_c"/>
          <speciesReference species="M_nad_c"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_nadh_c"/>
          <speciesReference species="M_nadp_c"/>
        </listOfProducts>
      </reaction>
      <reaction id="rR_SUCD4" reversible="false">
        <listOfReactants>
          <speciesReference species="M_q8h2_c"/>
          <speciesReference species="M_fad_c"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_q8_c"/>
          <speciesReference species="M_fadh2_c"/>
        </listOfProducts>
      </reaction>
      <reaction id="R_EX_ac_e_" reversible="false">
        <listOfReactants>
          <speciesReference species="M_ac_e"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_ac_b"/>
        </listOfProducts>
      </reaction>
      <reaction id="rR_EX_h2o_e_" reversible="false">
        <listOfReactants>
          <speciesReference species="M_h2o_b"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_h2o_e"/>
        </listOfProducts>
      </reaction>
      <reaction id="R_ATPS4r" reversible="false">
        <listOfReactants>
          <speciesReference species="M_pi_c"/>
          <speciesReference species="M_adp_c"/>
          <speciesReference species="M_h_e" stoichiometry="4"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_atp_c"/>
          <speciesReference species="M_h_c" stoichiometry="3"/>
          <speciesReference species="M_h2o_c"/>
        </listOfProducts>
      </reaction>
      <reaction id="R_PPCK" reversible="false">
        <listOfReactants>
          <speciesReference species="M_atp_c"/>
          <speciesReference species="M_oaa_c"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_adp_c"/>
          <speciesReference species="M_pep_c"/>
          <speciesReference species="M_co2_c"/>
        </listOfProducts>
      </reaction>
      <reaction id="R_MDH" reversible="false">
        <listOfReactants>
          <speciesReference species="M_mal_L_c"/>
          <speciesReference species="M_nad_c"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_nadh_c"/>
          <speciesReference species="M_oaa_c"/>
          <speciesReference species="M_h_c"/>
        </listOfProducts>
      </reaction>
      <reaction id="R_ADK1" reversible="false">
        <listOfReactants>
          <speciesReference species="M_atp_c"/>
          <speciesReference species="M_amp_c"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_adp_c" stoichiometry="2"/>
        </listOfProducts>
      </reaction>
      <reaction id="rR_EX_etoh_e_" reversible="false">
        <listOfReactants>
          <speciesReference species="M_etoh_b"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_etoh_e"/>
        </listOfProducts>
      </reaction>
      <reaction id="R_EX_glc_e_" reversible="false">
        <listOfReactants>
          <speciesReference species="M_glc_D_e"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_glc_D_b"/>
        </listOfProducts>
      </reaction>
      <reaction id="R_H2Ot" reversible="false">
        <listOfReactants>
          <speciesReference species="M_h2o_e"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_h2o_c"/>
        </listOfProducts>
      </reaction>
      <reaction id="R_CYTBD" reversible="false">
        <listOfReactants>
          <speciesReference species="M_o2_c" stoichiometry="0.5"/>
          <speciesReference species="M_q8h2_c"/>
          <speciesReference species="M_h_c" stoichiometry="2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_q8_c"/>
          <speciesReference species="M_h_e" stoichiometry="2"/>
          <speciesReference species="M_h2o_c"/>
        </listOfProducts>
      </reaction>
      <reaction id="R_EX_co2_e_" reversible="false">
        <listOfReactants>
          <speciesReference species="M_co2_e"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_co2_b"/>
        </listOfProducts>
      </reaction>
      <reaction id="R_ACt2r" reversible="false">
        <listOfReactants>
          <speciesReference species="M_ac_e"/>
          <speciesReference species="M_h_e"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_ac_c"/>
          <speciesReference species="M_h_c"/>
        </listOfProducts>
      </reaction>
      <reaction id="R_ADHEr" reversible="false">
        <listOfReactants>
          <speciesReference species="M_nadh_c" stoichiometry="2"/>
          <speciesReference species="M_accoa_c"/>
          <speciesReference species="M_h_c" stoichiometry="2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_etoh_c"/>
          <speciesReference species="M_nad_c" stoichiometry="2"/>
          <speciesReference species="M_coa_c"/>
        </listOfProducts>
      </reaction>
      <reaction id="R_ENO" reversible="false">
        <listOfReactants>
          <speciesReference species="M_2pg_c"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_pep_c"/>
          <speciesReference species="M_h2o_c"/>
        </listOfProducts>
      </reaction>
      <reaction id="rR_ADK1" reversible="false">
        <listOfReactants>
          <speciesReference species="M_adp_c" stoichiometry="2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_atp_c"/>
          <speciesReference species="M_amp_c"/>
        </listOfProducts>
      </reaction>
      <reaction id="rR_EX_succ_e_" reversible="false">
        <listOfReactants>
          <speciesReference species="M_succ_b"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_succ_e"/>
        </listOfProducts>
      </reaction>
      <reaction id="R_PIt" reversible="false">
        <listOfReactants>
          <speciesReference species="M_pi_c"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_pi_e"/>
        </listOfProducts>
      </reaction>
      <reaction id="rR_ACKr" reversible="false">
        <listOfReactants>
          <speciesReference species="M_actp_c"/>
          <speciesReference species="M_adp_c"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_ac_c"/>
          <speciesReference species="M_atp_c"/>
        </listOfProducts>
      </reaction>
      <reaction id="rR_EX_ac_e_" reversible="false">
        <listOfReactants>
          <speciesReference species="M_ac_b"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_ac_e"/>
        </listOfProducts>
      </reaction>
      <reaction id="R_NADH11" reversible="false">
        <listOfReactants>
          <speciesReference species="M_nadh_c"/>
          <speciesReference species="M_q8_c"/>
          <speciesReference species="M_h_c" stoichiometry="3"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_q8h2_c"/>
          <speciesReference species="M_nad_c"/>
          <speciesReference species="M_h_e" stoichiometry="2"/>
        </listOfProducts>
      </reaction>
      <reaction id="R_THD2" reversible="false">
        <listOfReactants>
          <speciesReference species="M_nadh_c"/>
          <speciesReference species="M_nadp_c"/>
          <speciesReference species="M_h_e" stoichiometry="2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_nadph_c"/>
          <speciesReference species="M_nad_c"/>
          <speciesReference species="M_h_c" stoichiometry="2"/>
        </listOfProducts>
      </reaction>
      <reaction id="R_ME2" reversible="false">
        <listOfReactants>
          <speciesReference species="M_mal_L_c"/>
          <speciesReference species="M_nadp_c"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_pyr_c"/>
          <speciesReference species="M_co2_c"/>
          <speciesReference species="M_nadph_c"/>
        </listOfProducts>
      </reaction>
      <reaction id="R_PFL" reversible="false">
        <listOfReactants>
          <speciesReference species="M_pyr_c"/>
          <speciesReference species="M_coa_c"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_accoa_c"/>
          <speciesReference species="M_for_c"/>
        </listOfProducts>
      </reaction>
      <reaction id="rR_EX_for_e_" reversible="false">
        <listOfReactants>
          <speciesReference species="M_for_b"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_for_e"/>
        </listOfProducts>
      </reaction>
      <reaction id="R_EX_akg_e_" reversible="false">
        <listOfReactants>
          <speciesReference species="M_akg_e"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_akg_b"/>
        </listOfProducts>
      </reaction>
      <reaction id="R_RPI" reversible="false">
        <listOfReactants>
          <speciesReference species="M_r5p_c"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_ru5p_D_c"/>
        </listOfProducts>
      </reaction>
      <reaction id="rR_D_LACt2" reversible="false">
        <listOfReactants>
          <speciesReference species="M_lac_D_c"/>
          <speciesReference species="M_h_c"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_lac_D_e"/>
          <speciesReference species="M_h_e"/>
        </listOfProducts>
      </reaction>
      <reaction id="R_PGL" reversible="false">
        <listOfReactants>
          <speciesReference species="M_6pgl_c"/>
          <speciesReference species="M_h2o_c"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="M_6pgc_c"/>
          <speciesReference species="M_h_c"/>
        </listOfProducts>
      </reaction>
    </listOfReactions>
  </model>
</sbml>
